The USAID- and PEPFAR-funded global CapacityPlus project assisted PEPFAR countries to identify and address human resources for health (HRH) challenges to accelerate progress toward national HIV goals and the vision of an AIDS-free generation.There are many approaches, achievements, and lessons learned from CapacityPlus’s work that can be leveraged to advance implementation of the PEPFAR 3.0 agenda and the new PEPFAR HRH strategy. This technical brief presents these for each objective of the PEPFAR HRH strategy.