The purpose of this manual is to provide prime partners with the basic resources and knowledge to support and capacitate subawards in applying for and managing grants as a prime. This manual is intended to respond to this PEPFAR announcement by providing guidelines on how primes can build capacity at LPs; and is guided by US Government (USG) rules, regulations, and requirements (e.g., ADS 302, 303, 312, 2CFR 200).